Python Django is a high-level Python web framework that enables rapid development of secure and maintainable websites. Built by experienced developers, Django takes care of much of the hassle of web development, so you can focus on writing your app without needing to reinvent the wheel. It is free and open source, has a thriving and active community, great documentation, and many options for free and paid-for support.
Django helps developers avoid many common security mistakes by providing a framework that has been engineered to "do the right things" to protect the website automatically. For example, Django provides a secure way to manage user accounts and passwords, avoiding common mistakes like putting session information in cookies where it is vulnerable (instead cookies just contain a key, and the actual data is stored in the database) or directly storing passwords rather than a password hash.
Django web applications manage and query data through Python objects referred to as models. Models define the structure of stored data, including the field types and possibly also their maximum size, default values, selection list options, help text for documentation, label text for forms, etc. The definition of the model is independent of the underlying database — you can choose one of several as part of your project settings. Once you've chosen what database you want to use, you don't need to talk to it directly at all — you just write your model structure and other code, and Django handles all the "dirty work" of communicating with the database for you.